Recent Advances in the Chemistry of Melanogenesis in Mammals
Journal of Investigative Dermatology (1980) 75, 122–127; doi:10.1111/1523-1747.ep12521344
Istituto di Chimica Organica e Biologica dell'Universita, Napoli, Italy
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The color of mammalian hair, skin, eyes results mainly from the secretory products of melanocytes. These secretory products consist of a wide range of melanin pigments with different structures compositions. These include black or brown nitrogenous eumelanins; yellow or reddish brown, sulfur-containing pheomelanins, e.g., the trichoomes of low molecular weight; other pigments whose chemical physical properties are intermediate between those of typical eumelanins pheomelanins. Despite the evident differences in molecular size general properties, all these pigments are biogenetically related, they arise from a common metabolic pathway in which dopaquinone is the key intermediate. The current state of knowledge on the molecular mechanisms governing the metabolic fate of dopaquinone in melanocytes is discussed with special reference to the role of such sulfhydryl compounds as cysteine glutathione in melanogenesis.
哺乳動(dòng)物體內(nèi)色素色素生化反應(yīng)的研發(fā)進(jìn)展
皮膚醫(yī)科學(xué)刊，1980,75卷122-127頁
意大利那波里戴爾大學(xué)，生化系
摘要
哺乳類動(dòng)物、毛發(fā)、皮膚、眼睛內(nèi)的色素都源自色素細(xì)胞產(chǎn)生的不同色素。色素有不同的結(jié)構(gòu)及成份。包括黑色、棕色的含氮evmelanin色素及黃及紅棕色的含硫的pheomelanins，并主宰了毛發(fā)中低原子量的色素。其他色素介于以上兩者之間，所有色素從組成、結(jié)構(gòu)來說都來自鉻氨酸代謝出的中間產(chǎn)物dopaquinone,而dopanquinone在轉(zhuǎn)變?yōu)楦鞣N不同色素過程中都會(huì)受到含有巰氧基的半胱氨酸及還原型谷胱甘肽阻斷。
Journal of Investigative Dermatology (1980) 75, 122–127; doi:10.1111/1523-1747.ep12521344
Istituto di Chimica Organica e Biologica dell'Universita, Napoli, Italy
Top of page
tract
The color of mammalian hair, skin, eyes results mainly from the secretory products of melanocytes. These secretory products consist of a wide range of melanin pigments with different structures compositions. These include black or brown nitrogenous eumelanins; yellow or reddish brown, sulfur-containing pheomelanins, e.g., the trichoomes of low molecular weight; other pigments whose chemical physical properties are intermediate between those of typical eumelanins pheomelanins. Despite the evident differences in molecular size general properties, all these pigments are biogenetically related, they arise from a common metabolic pathway in which dopaquinone is the key intermediate. The current state of knowledge on the molecular mechanisms governing the metabolic fate of dopaquinone in melanocytes is discussed with special reference to the role of such sulfhydryl compounds as cysteine glutathione in melanogenesis.
哺乳動(dòng)物體內(nèi)色素色素生化反應(yīng)的研發(fā)進(jìn)展
皮膚醫(yī)科學(xué)刊，1980,75卷122-127頁
意大利那波里戴爾大學(xué)，生化系
摘要
哺乳類動(dòng)物、毛發(fā)、皮膚、眼睛內(nèi)的色素都源自色素細(xì)胞產(chǎn)生的不同色素。色素有不同的結(jié)構(gòu)及成份。包括黑色、棕色的含氮evmelanin色素及黃及紅棕色的含硫的pheomelanins，并主宰了毛發(fā)中低原子量的色素。其他色素介于以上兩者之間，所有色素從組成、結(jié)構(gòu)來說都來自鉻氨酸代謝出的中間產(chǎn)物dopaquinone,而dopanquinone在轉(zhuǎn)變?yōu)楦鞣N不同色素過程中都會(huì)受到含有巰氧基的半胱氨酸及還原型谷胱甘肽阻斷。
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