紫外線輻射減低表皮中谷胱甘肽的含量
DEPLETION OF CUTANEOUS GLUTATHIONE BY ULTRAVIOLET RADIATION?
Michael J. Connor1,*, Larry A. Wheeler2Article first published online: 2 JAN 2008
DOI: 10.1111/j.1751-1097.1987.tb04762.x
Volume 46, Issue 2, pages 239–245, August 1987
tract
Supplemental antioxidants may have a role in ameliorating or preventing the actinic damage that can lead to cutaneous disorders such as skin cancer, hyper pigmentation, premature aging. Glutathione is an ant endogenous antioxidant fulfills various protective functions in the skin. Irradiation of hairless mice with short (UVB) or long (UVA) wavelength ultraviolet radiation or with UVA combined with a photosensitizing psoralen (PUVA) can deplete skin glutathione levels. Ultraviolet B irradiation causes rapid transient fluctuations in the epidermal glutathione level the relative amount present as the oxidized form. Ultraviolet A irradiation can deplete epidermal dermal glutathione for several hours but requires much higher doses than UVB. PUVA treatments may lead to extensive prolonged depletions of epidermal dermal glutathione, the severity of which is dependent on the psoralen dose may last for several days. These transient depletions, oxidations, sometimes rapid recoveries of cutaneous glutathione levels are compatible with a role for glutathione as an endogenous photoprotective agent in the skin. erimental evidence supports such a role: for example severe skin edema develops in mice only after about 50% of the glutathione has been depleted by PUVA treatment. Although different mechanisms are involved in each case, glutathione depletion may contribute to the production of phototoxicity by UVB, UVA, by PUVA. Understing the depletion mechanisms may allow the development of strategies aimed at preventing loss of cutaneous glutathione, at reinforcing the natural protective functions of this critical cell component.
邁克.康納 教授 ， 萊瑞.輝勒 教授
洛杉磯加州大學(xué)醫(yī)學(xué)院
2008年1月2號(hào)
光化學(xué)及光生物學(xué)刊
1987，第46期，239-245頁(yè)
摘要
額外補(bǔ)充的抗氧化劑可以舒緩或預(yù)防太陽(yáng)光照射對(duì)皮膚的危害。譬如，皮膚癌、色斑及皮膚提前衰老，谷胱甘肽是重要內(nèi)源性產(chǎn)生的抗氧化劑，谷胱甘肽可以完成各種抗氧化劑對(duì)皮膚保護(hù)的需求。除毛后的老鼠用長(zhǎng)短波紫外線（UVA,UVB）及UVA加上PUVA照射后實(shí)驗(yàn)數(shù)據(jù)顯示老鼠皮質(zhì)內(nèi)的谷胱甘肽含量都會(huì)大量減少。UVB造成鼠皮內(nèi)還原型的谷胱甘肽間斷性的減少及轉(zhuǎn)變?yōu)檠趸凸入赘孰?。高量的UVA能持續(xù)數(shù)小時(shí)的降低皮膚內(nèi)谷胱甘肽的含量。PUVA能更強(qiáng)的降低老鼠皮膚內(nèi)谷胱甘肽的含量達(dá)數(shù)日之久。皮膚內(nèi)谷胱甘肽受到紫外線輻射后降低含量原因是谷胱甘肽保護(hù)皮膚遭到輻射的侵害后中和輻射產(chǎn)生的自由基，還原型的谷胱甘肽與自由基作用轉(zhuǎn)變?yōu)檠趸偷墓入赘孰?。?shí)驗(yàn)數(shù)據(jù)證明在老鼠皮膚內(nèi)，因PUVA照射，皮膚內(nèi)還原型谷胱甘肽降至50%以下時(shí)，皮膚水腫就會(huì)發(fā)生。實(shí)驗(yàn)證明，當(dāng)皮膚內(nèi)谷胱甘肽降低時(shí)，皮膚就無(wú)法避免紫外線照射的毒害。根據(jù)本文實(shí)驗(yàn)的結(jié)果，我們要思考如何保持及補(bǔ)充皮膚內(nèi)谷胱甘肽的含量以應(yīng)對(duì)太陽(yáng)紫外線輻射對(duì)皮膚的毒害。
